Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice
Identifieur interne : 000B45 ( Main/Exploration ); précédent : 000B44; suivant : 000B46Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice
Auteurs : JIANZHONG SHI [République populaire de Chine] ; ZHIYUAN WEN [République populaire de Chine] ; JING GUO [République populaire de Chine] ; YING ZHANG [République populaire de Chine] ; GUOHUA DENG [République populaire de Chine] ; YUELONG SHU [République populaire de Chine] ; DAYAN WANG [République populaire de Chine] ; YONGPING JIANG [République populaire de Chine] ; Yoshihiro Kawaoka [Japon] ; ZHIGAO BU [République populaire de Chine] ; HUALAN CHEN [République populaire de Chine]Source :
- Antiviral research [ 0166-3542 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Vaccination is a key strategy for preventing influenza virus infections. Here, we generated a reassortant virus (SC/AAca) containing the hemagglutinin and neuraminidase genes from a 2009 pandemic influenza virus A/Sichuan/1/2009 (H1N1) (SC/09) and six internal genes from the cold-adapted virus A/Ann Arbor/ 6/60 (H2N2) (AAca). The SC/AAca reassortant induced a sound humoral immune response and complete protection against homologous SC/09 virus challenge in mice after intranasal administration of an at least 106 50% egg infectious dose (EID50) of SC/AAca. SC/AAca inoculation also induced significant CD4+ and CD8+ T cell responses and provided solid protection against heterologous H1N1 and H5N1 virus challenge. Our results suggest that this 2009 H1N1 live vaccine will provide protection against both 2009 pandemic and seasonal H1N1 virus infection and might reduce the severity of H5N1 virus infection in humans. The induction of cross-reactive virus-specific T cell responses may be an effective approach to develop universal influenza vaccines.
Affiliations:
- Japon, République populaire de Chine
- Région de Kantō, Wisconsin
- Madison (Wisconsin), Pékin, Tokyo
- Université de Tokyo, Université du Wisconsin à Madison
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Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street</s1><s2>Harbin 150001</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Yuelong Shu" sort="Yuelong Shu" uniqKey="Yuelong Shu" last="Yuelong Shu">YUELONG SHU</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Institute for Viral Disease Control and Prevention, China CDC, 100 Yingxin Street</s1><s2>Beijing 100052</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Dayan Wang" sort="Dayan Wang" uniqKey="Dayan Wang" last="Dayan Wang">DAYAN WANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Institute for Viral Disease Control and Prevention, China CDC, 100 Yingxin Street</s1><s2>Beijing 100052</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yongping Jiang" sort="Yongping Jiang" uniqKey="Yongping Jiang" last="Yongping Jiang">YONGPING JIANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Animal Influenza Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street</s1><s2>Harbin 150001</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Division of Virology, Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo</s1><s2>Tokyo 108-8639</s2><s3>JPN</s3><sZ>9 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation></author><author><name sortKey="Zhigao Bu" sort="Zhigao Bu" uniqKey="Zhigao Bu" last="Zhigao Bu">ZHIGAO BU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Animal Influenza Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street</s1><s2>Harbin 150001</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Hualan Chen" sort="Hualan Chen" uniqKey="Hualan Chen" last="Hualan Chen">HUALAN CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Animal Influenza Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street</s1><s2>Harbin 150001</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0179380</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0179380 INIST</idno><idno type="RBID">Pascal:12-0179380</idno><idno type="wicri:Area/PascalFrancis/Corpus">000005</idno><idno type="wicri:Area/PascalFrancis/Curation">000069</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000003</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000003</idno><idno type="wicri:doubleKey">0166-3542:2012:Jianzhong Shi:protective:efficacy:of</idno><idno type="wicri:Area/Main/Merge">000B48</idno><idno type="wicri:Area/Main/Curation">000B45</idno><idno type="wicri:Area/Main/Exploration">000B45</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Protective efficacy of an H1N1 cold-adapted live vaccine against the 2009 pandemic H1N1, seasonal H1N1, and H5N1 influenza viruses in mice</title><author><name sortKey="Jianzhong Shi" sort="Jianzhong Shi" uniqKey="Jianzhong Shi" last="Jianzhong Shi">JIANZHONG SHI</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Animal Influenza Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street</s1><s2>Harbin 150001</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Zhiyuan Wen" sort="Zhiyuan Wen" uniqKey="Zhiyuan Wen" last="Zhiyuan Wen">ZHIYUAN WEN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Animal Influenza Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street</s1><s2>Harbin 150001</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Jing Guo" sort="Jing Guo" uniqKey="Jing Guo" last="Jing Guo">JING GUO</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Animal Influenza Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street</s1><s2>Harbin 150001</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Ying Zhang" sort="Ying Zhang" uniqKey="Ying Zhang" last="Ying Zhang">YING ZHANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Animal Influenza Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street</s1><s2>Harbin 150001</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Guohua Deng" sort="Guohua Deng" uniqKey="Guohua Deng" last="Guohua Deng">GUOHUA DENG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Animal Influenza Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street</s1><s2>Harbin 150001</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Yuelong Shu" sort="Yuelong Shu" uniqKey="Yuelong Shu" last="Yuelong Shu">YUELONG SHU</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Institute for Viral Disease Control and Prevention, China CDC, 100 Yingxin Street</s1><s2>Beijing 100052</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Dayan Wang" sort="Dayan Wang" uniqKey="Dayan Wang" last="Dayan Wang">DAYAN WANG</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Institute for Viral Disease Control and Prevention, China CDC, 100 Yingxin Street</s1><s2>Beijing 100052</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yongping Jiang" sort="Yongping Jiang" uniqKey="Yongping Jiang" last="Yongping Jiang">YONGPING JIANG</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Animal Influenza Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street</s1><s2>Harbin 150001</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Division of Virology, Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo</s1><s2>Tokyo 108-8639</s2><s3>JPN</s3><sZ>9 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation></author><author><name sortKey="Zhigao Bu" sort="Zhigao Bu" uniqKey="Zhigao Bu" last="Zhigao Bu">ZHIGAO BU</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Animal Influenza Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street</s1><s2>Harbin 150001</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author><author><name sortKey="Hualan Chen" sort="Hualan Chen" uniqKey="Hualan Chen" last="Hualan Chen">HUALAN CHEN</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Animal Influenza Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street</s1><s2>Harbin 150001</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Harbin 150001</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Antiviral research</title><title level="j" type="abbreviated">Antivir. res.</title><idno type="ISSN">0166-3542</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Antiviral research</title><title level="j" type="abbreviated">Antivir. res.</title><idno type="ISSN">0166-3542</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Attenuated strain</term><term>Common cold</term><term>Efficiency</term><term>H1N1 influenza</term><term>Influenzavirus A(H5N1)</term><term>Mouse</term><term>Prevention</term><term>Seasonal variation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Prévention</term><term>Efficacité</term><term>Rhume banal</term><term>Souche atténuée</term><term>Variation saisonnière</term><term>Animal</term><term>Souris</term><term>Influenzavirus A(H1N1)</term><term>Grippe H1N1</term><term>Influenzavirus A(H5N1)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vaccination is a key strategy for preventing influenza virus infections. Here, we generated a reassortant virus (SC/AAca) containing the hemagglutinin and neuraminidase genes from a 2009 pandemic influenza virus A/Sichuan/1/2009 (H1N1) (SC/09) and six internal genes from the cold-adapted virus A/Ann Arbor/ 6/60 (H2N2) (AAca). The SC/AAca reassortant induced a sound humoral immune response and complete protection against homologous SC/09 virus challenge in mice after intranasal administration of an at least 10<sup>6</sup> 50% egg infectious dose (EID<sub>50</sub>) of SC/AAca. SC/AAca inoculation also induced significant CD4+ and CD8+ T cell responses and provided solid protection against heterologous H1N1 and H5N1 virus challenge. Our results suggest that this 2009 H1N1 live vaccine will provide protection against both 2009 pandemic and seasonal H1N1 virus infection and might reduce the severity of H5N1 virus infection in humans. The induction of cross-reactive virus-specific T cell responses may be an effective approach to develop universal influenza vaccines.</div></front></TEI><affiliations><list><country><li>Japon</li><li>République populaire de Chine</li></country><region><li>Région de Kantō</li><li>Wisconsin</li></region><settlement><li>Madison (Wisconsin)</li><li>Pékin</li><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li><li>Université du Wisconsin à Madison</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Jianzhong Shi" sort="Jianzhong Shi" uniqKey="Jianzhong Shi" last="Jianzhong Shi">JIANZHONG SHI</name></noRegion><name sortKey="Dayan Wang" sort="Dayan Wang" uniqKey="Dayan Wang" last="Dayan Wang">DAYAN WANG</name><name sortKey="Guohua Deng" sort="Guohua Deng" uniqKey="Guohua Deng" last="Guohua Deng">GUOHUA DENG</name><name sortKey="Hualan Chen" sort="Hualan Chen" uniqKey="Hualan Chen" last="Hualan Chen">HUALAN CHEN</name><name sortKey="Jing Guo" sort="Jing Guo" uniqKey="Jing Guo" last="Jing Guo">JING GUO</name><name sortKey="Ying Zhang" sort="Ying Zhang" uniqKey="Ying Zhang" last="Ying Zhang">YING ZHANG</name><name sortKey="Yongping Jiang" sort="Yongping Jiang" uniqKey="Yongping Jiang" last="Yongping Jiang">YONGPING JIANG</name><name sortKey="Yuelong Shu" sort="Yuelong Shu" uniqKey="Yuelong Shu" last="Yuelong Shu">YUELONG SHU</name><name sortKey="Zhigao Bu" sort="Zhigao Bu" uniqKey="Zhigao Bu" last="Zhigao Bu">ZHIGAO BU</name><name sortKey="Zhiyuan Wen" sort="Zhiyuan Wen" uniqKey="Zhiyuan Wen" last="Zhiyuan Wen">ZHIYUAN WEN</name></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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